KARAKTERISASI SENYAWA ANALGETIKA-ANTIINFLAMASI N-(4t-BUTILBENZOIL)-p-AMINOFENOL YANG DISINTISES DENGAN KATALIS ASAM

  • Hadi Barru Hakam Fajar Siddiq
Keywords: N-(4t-butyl benzoil)-p-aminophenol, catalyst

Abstract

The N-(4t-Butylbenzoyl)-p-Aminophenol compound was a synthesis compound between p-aminophenol and 4t-Butylbenzoyl chloride by using H2SO4 catalyst. The addition of H2SO4 catalyst purposed to accelerate the rate of rection in the synthesis of the compound and increased yield of product. The N-(4t-Butylbenzoil)-p-Aminophenol compound is beneficial as an antiinflammatory analgesic. This research were proposed to determine characteristics of the anti-inflammatory analgesic synthesis of N-(4t-Butylbenzoyl)-p-Aminophenol compound by using H2SO4 catalyst. Characterization conducted in this research were physical and chemical characterization. The physical characterization were organoleptic test, crystal form test and melting point test. While chemical characterization were UV-Vis spectrophotometry and FTIR. Result of organoleptic test showed sample had powder form, white-gray colour and not taste. Melting point of N-(4t-Butylbenzoyl)-p-Aminophenol compound was 193.33 °C. The optimum wavelength of UV-Vis spectrophotometry got 2 peaks at the wavelengths 290 and 295 nm. The result of FTIR showed that N-(4t-Butylbenzoyl)-p-Aminophenol compound had peaks.

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References

Arfah, M., Mappiratu, Razak, AR. 2015. Optimasi Reaksi Esterifikasi Asam Laurat dengan Metanol Menggunakan Katalis Asam Sulfat Pekat. Jurnal Online of Natural Science. Vol. 4. No. 1. Hal. 46-55.
Ngadiwiyana. 2005. Polimerisasi Eugenol dengan Katalis Asam Sulfat Pekat. JSKA. Vol. VIII. No.2.
Setyadji, M. 2007. Hidrolisis Pentosan Menjadi Furufal dengan Katalisator Asam Sulfat untuk Meningkatkan Kualitas Bahan Bakar Mesin Diesel. Prosiding PPI-PDIPTN Pustek Akselerator dan Proses Bahan-Batan. ISSN 0216-3128. Hal. 159-165.
Soekardjo, B. 1997. Sintesis dan Uji Aktivitas Antibakteri Senyawa 3,4 diklorobenzoil-N-ampisillin. Cermin Dunia Farmasi, Vol. 34. Halaman 28-31.
Susilowati, S.S, dan Handayani, S.N. 2006. Sintesis dan Uji Aktivitas Analgetika-Antiinflamasi Senyawa N-(4t-butilbenzoil)-p-Aminofenol. Molekul. Vol.1. No. 1. Hal. 36-40.
Willette, R.E. 1982. Analgesic Agents, dalam J.N. Delgado dan W. A. Remers (eds.) Wilson and Gisvold’s. Textbook of Organic Medicinal and Pharmacetical Chemistry, 8th Ed. J.B. Lippincott. Philadelphia.
Published
2018-07-25